THE story of Alice Pyne, the Ulverston teenager whose life-threatening blood cancer prompted a search for a bone marrow donor back in 2011, touched the lives of many people in Furness.
One such person was Josh Cain. Then a 17-year-old, he was one of thousands of people who signed up to the register run by the charity Anthony Nolan in the hope that he would be the match which might save her life.
Even when Alice was told that her Hodgkin’s lymphoma had become terminal, meaning no further treatment would help her, she continued to campaign to get more people to sign up to be bone marrow, or stem cell, donors.
And it is a testament to her inspiring spirit that, four years after Alice’s death, Josh, of Meadowlands Avenue, Barrow, has potentially saved the life of another person.
“I saw on Facebook that Alice was looking for a donor, and then it was on her bucket list. I wanted to help, so I went and did it online,” says Josh, 25, a BAE Systems worker.
When his "spit kit" arrived, Josh completed it, popped the prepaid envelope in the postbox and didn’t hear anything until an email from Anthony Nolan landed in his inbox around one year ago.
“It said that I was a potential match for someone and asked me to do a blood test,” he adds.
When a total of 10 vials arrived, Josh might have been forgiven for feeling a little daunted. Far from it, says the modest young lad, who maintains that his overriding emotion has been "excited" since day one.
After sending off his blood, however, Anthony Nolan informed him that the procedure had been put off because his match was not healthy enough. They’d be back in touch if he was needed. Josh carried on, waiting and wondering about the fate of the patient.
Three weeks ago, everything changed. Josh received a call to say the procedure was going ahead, triggering a rapid sequence of events.
“Anthony Nolan sent me everything I needed to know, and all my expenses were covered by the charity,” he explains.
As Josh learned, there are two procedures which donors can complete - a bone marrow donation, which involves an operation, or through peripheral blood stem cell donation. In around 90 per cent of cases, including Josh, it’s the latter.
Before a person can receive a donation of blood stem cells from a suitable donor, they will be given high dosages of chemotherapy, and possibly radiation therapy in order to completely destroy all the diseased cells in their body. They can often be an hour away from death; the reason that, once the go-ahead is given, everything is done at an accelerated pace.
First came a medical in London. A few days later, Josh was put on a course of four growth hormones which involved a nurse visiting his house and administering injections designed to create an excess of stem cells which multiply into the bloodstream.
Days later he was in the London Clinic hospital where the stem cells were extracted from one arm, and his blood returned to the other.
He spent four hours in a bed with his proud girlfriend Claudia Little, 20, at his side. An overnight stay to ensure the hospital had enough cells followed.
“They warn you about all the side effects and they are always asking if you’re OK, they want to prepare you as much as possible,” said Josh.
“I wasn’t really fazed by any of it, I’m not squeamish at all and I was just excited that I could be helping someone. I feel proud to have done it.”
As for side effects, he says, they have been few and far between.
“I’ve felt a bit of fatigue but not a lot other than that,” says Josh, who has been supported by BAE Systems throughout the process.
All the charity will say at this stage is that the recipient is an adult male and he can send a card anonymously through the charity. In two years' time, he can find out whether the procedure worked - and the recipient can choose to get in touch.
“You only know a rough age and gender. I decided I wanted to know if it is a success, but I want to send a card either way,” said Josh.
Witnessing the work of Anthony Nolan first hand has inspired Josh to raise awareness and funds for the charity. The only criteria for donors is that they’re healthy, and aged between 16 and 30.
It is particularly keen to get healthy young men like Josh on the list. At the moment, they only make up 15 per cent of those signed up, and last year a YouGov survey found that 34 per cent of young men who wouldn’t sign up as a stem cell donor were just too scared that the experience would be painful.
Which is why Josh is starting by sharing his own experience. And his message to those who aren’t on the register?
He said: “Definitely do it, even if you’re a bit scared of needles.
“Whatever you have to do when you’re donating, it’s absolutely nothing compared to what people with blood cancer are going through.”
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